Indapamide dosage, side effects

Indapamide dosage, side effects:

Indapamide is a thiazide-like diuretic and antihypertensive medication primarily used to treat hypertension (high blood pressure) and edema (fluid retention) associated with heart failure.

Brand Names of Indapamide

Indapamide is sold under various brand names worldwide, including:

Common Brand Names:

• Lozol (U.S., Canada, and some European countries)
• Natrilix (Australia, Europe, South Africa)
• Indamol (UK)
• Fludex (France)
• Tertensif (some European countries)
• Ipamix (Italy)
• Pamide (India)
• Natrilex (Brazil)
• Dapa-tabs (South Africa)

Combination Brands (Indapamide + Other Drugs):

• Preterax (Indapamide + Perindopril) – Used for hypertension in Europe.
• Coversyl Plus (Indapamide + Perindopril) – Another combination for hypertension.
• Vasodip (Indapamide + Lisinopril) – Used in some countries.

Key Features of Indapamide:

• Class: Thiazide-like diuretic (sulfonamide derivative).
• Mechanism of Action: Acts on the distal convoluted tubules in the kidneys to promote sodium and water excretion, reducing blood volume and blood pressure.
• Uses:
  • Hypertension (first-line treatment).
  • Edema due to heart failure.
• Dosage Forms: Typically 1.25 mg, 2.5 mg tablets (sometimes SR/XL extended-release versions).
• Side Effects:
  • Electrolyte imbalances (low potassium, sodium, magnesium).
  • Increased urination (diuretic effect).
  • Dizziness, headache, muscle cramps.
  • Rarely: Photosensitivity, gout (due to increased uric acid).
• Contraindications:
  • Severe kidney/liver impairment.
  • Hypersensitivity to sulfonamides.
  • Severe hypokalemia (low potassium).

Comparison to Other Diuretics:

• Similar to hydrochlorothiazide (HCTZ) but with a longer half-life (often dosed once daily).
• May have less potassium loss compared to some thiazides.